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---Procedencia: 
 Institución:IDIBAPS
 Contacto correo-e:[log in para visualizar]
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The position

We offer a pre-doctoral contract as a PhD student in Liver Cell Plasticity and Tissue Repair Group at IDIBAPS. The selected candidate will participate in the project “Assessing cell plasticity in chronic liver disease: from organoids to therapeutic targets”. The project aims to dissect the molecular pathways regulating hepatocyte plasticity and reprogramming in the context of chronic liver diseases, involving:

· Humans sample processing

· 3D culture system including patient-derived organoids and iPSCs-derived spheroids

· Animal models

· High-throughput analysis including transcriptomic and proteomic data


What do we look for?

· Candidate with degree in biomedicine/engineering or related disciplines

· Experience in cell culture, animal handling and/or bioinformatics

· Competencies and skills: Communication, Teamwork and collaboration, Commitment, Proactivity, Integrity, Critical and Analytical thinking

· Good level of English


Main tasks and responsibilities:

· Generate patient-derived organoids for functional assessment

· Generate genetic engineered patient-derived organoids

· Investigate mechanisms of disease in mouse models of liver injury

· Evaluate genomic and proteomic data from patients with chronic liver disease


Research group

The candidate will be part of a the research group Liver Cell Plasticity and Tissue Repair led by Dr. Pau Sancho-Bru, located at IDIBAPS (https://www.clinicbarcelona.org/en/idibaps/research-areas/liver-digestive-system-and-metabolism/liver-cell-plasticity-and-tissue-repair).

The group is a leader in the field of liver injury and stem cell research as demonstrated by high impact factor publications (Ariño et al. J Hepatol 2023; Aguilar-Bravo J Hepatol 2023; Vallverdu-Martínez et al. Nat Protoc 2021; Coll et al. Cell Stem Cell 2018).


How to apply?

If you are interested to join us, Please send your CV and a letter of motivation to Pau Sancho-Bru: [log in para visualizar]

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Información complementaria de la oferta:
For any other information, please visit our website: https://www.clinicbarcelona.org/ca/idibaps/arees-i-programes/fetge-sistema-digestiu-i-metabolisme/plasticitat-i-reparacio-tissular-en-malalties-hepatiques