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---Procedencia: 
 Institución:CIC bioGUNE
 Contacto correo-e:[log in para visualizar]
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PhD Fellowship Opportunity in Magnesium Signaling Research
We are thrilled to announce a FPI fellowship associated Proyectos de Generación de Conocimiento 2024 for a PhD thesis at Dr. Malu Martinez Chantar's Liver Disease Lab at CIC bioGUNE, Vizcaya. The project, titled "Exploring Magnesium's Signaling Role in Type 2 Diabetes and Aging: Transformative Perspectives in Magnesium Research (MAGNIT2D)", offers a unique opportunity to delve into groundbreaking research on magnesium's role in metabolic health and disease.
Project Overview: Despite the well-known effects of intracellular Mg2+ concentrations, the intricate regulation of these concentrations by ion channels and transporters remains poorly understood. This project aims to illuminate the role of Mg2+ transporters, which exhibit significant dysregulation in metabolically compromised organs, in the development of Mg2+-related disturbances associated with "inflammaging" and Type 2 Diabetes (T2D), including mitochondrial dysfunction, genomic instability, and reactive oxygen species production. Specifically, our objective is to unravel the systemic regulation of this essential "messenger cation" in metabolically compromised tissues such as the liver, adipose tissue, pancreas, and brain. By delving into this investigation, we aspire to enhance our understanding of the impact of Mg2+ and Mg2+ transporters on the onset and progression of T2D.
Recent Publications from Our Group:
•	Hepatology. 2024 May 1;79(5):1158-1179. doi: 10.1097/HEP.0000000000000341
•	Cell Rep Med. 2024 Jul 16;5(7):101653. doi: 10.1016/j.xcrm.2024.101653.
•	Cell Rep. 2024 Mar 26;43(3):113924. doi: 10.1016/j.celrep.2024.113924.
•	Cell Metab. 2023 Sep 5;35(9):1630-1645.e5. doi: 10.1016/j.cmet.2023.07.003
•	Cell Metab. 2023 Aug 8;35(8):1373-1389.e8. doi: 10.1016/j.cmet.2023.07.002
•	Hepatology. 2023 May 1;77(5):1654-1669. doi: 10.1002/hep.32705.
•	Hepatology. 2023 Sep 1;78(3):878-895. doi: 10.1097/HEP.0000000000000303
What We Are Looking For: We seek a motivated researcher with initiative, a strong capacity for study, and a passion for science. This is an excellent opportunity to join a leading research team and contribute to impactful scientific discoveries.
Application Details:
•	Interested candidates should send a motivation letter and CV to [log in para visualizar]
•	The start date for this fellowship is between December 2024 and January 2025.
Join us at CIC bioGUNE and be a part of transformative research that could significantly advance our understanding of magnesium's role in metabolic diseases and aging. We look forward to your application!



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Información complementaria de la oferta:
Interested candidates should send a motivation letter and CV to [log in para visualizar]
•	The start date for this fellowship is between December 2024 and January 2025.
Join us at CIC bioGUNE and be a part of transformative research that could significantly advance our understanding of magnesium's role in metabolic diseases and aging. We look forward to your application!